Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine, Single Volume

Product Details
»Book Publisher: Saunders (20 October, 2004)
»ISBN: 072160479X
»Book author: Eugene Braunwald, Douglas P. Zipes, Peter Libby, Robert Bonow

Book Description:
With 35 new chapters as well as comprehensive updates throughout, the New Edition of the cardiology masterwork represents the most complete revision to date. Hundreds of world authorities synthesize all of the developments that are revolutionizing practicefrom the newest findings in molecular biology and genetics to the latest imaging modalities, interventional procedures, and medications. Plus, it now features an exciting full-color layout with many new illustrations, a brand-new section on preventive cardiology, 20 new contributors, and a wealth of e-dition options to meet any reference need.

Download Here :

Part 1
Part 2
Part 3
Part 4
Part 5
Part 6

Pediatric ENT

Product Details

»Book Publisher: Springer (October, 2007)
»ISBN: 3540330380
»Book author: John M. Graham, Glenis K. Scadding, Peter D. Bull

Book Description:

In recent years there has been increasing sub-specialization and a rapid expansion of the range of therapies available to pediatric ENT specialists. This concise, up-to-date textbook deals comprehensively with all the practical and theoretical aspects necessary for those taking exams or wishing to up-date their knowledge. It is divided into sections covering rhinology, otology and head and neck problems. The uniformly structured chapters cover all relevant topics comprehensively and succinctly. The authors are from Europe and the US and are internationally renowned experts in their fields. This useful and reader-friendly textbook will not only be inspirational to young specialists with an interest in pediatric ENT, but also to those who are due to take their final exams as well as for established specialists in the field.


Download Here >>>

Evidence-Based Pediatric Oncology (Evidence-Based)

Product Details
»Book Publisher: Blackwell Publishing Limited (01 April, 2007)
»ISBN: 1405142685
»Book author: Katherine Matthay, Joann Ater, Alan Craft, Timothy Eden, Judith Chessells, Beatrice Fervers, Meriel Jenney, Vaskar Saha, Ross Pinkerton, A. G. Shankar

Book Description:
Evidence-based Pediatric Oncology is a ground breaking text on the management of childhood cancers. Using evidence-based treatment recommendations from available systematic reviews and Standard Options Recommendations (SORs), it covers the range of tumour types occurring in children and young adults with recommendations for optimum treatments for childhood cancer.Offering reviews and commentaries from leading internationally recognised pediatric oncologists, this second edition now covers significant randomized controlled trails.

Download Here >>>

Color Atlas of Congenital Heart Surgery

Product Details

»Book Publisher: Springer (12 June, 2007)
»ISBN: 0387354158
»Book author: S. Bert Litwin

Book Description:

Color Atlas of Congenital Heart Surgery covers the full spectrum of congenital heart defects, first depicting the pathology in pre-repair photographs and then detailing step-by-step the operative procedure. Dr. Litwin depicts the most common procedures along with the most complex ones, providing a range of information vital to residents and fellows in training as well as clinicians in practice.

One of the key aspects of the utility and practicality of Color Atlas of Congenital Heart Surgery is the unique perspective of the operative photos. Using a special side-mounted flash, the author s photographs vividly capture the three dimensional spatial relations of congenital anomalies and surgical anatomy. Additionally, each illustration and photo is extensively labeled for clarity (indicating the patient s left, right, cephalad and caudad positions).

With over 100 new illustrations and many new procedures, the new edition of Color Atlas of Congenital Heart Surgery is both a textbook and an atlas, providing an indispensable reference for every surgeon, cardiologist, intensivist, or anesthetist who treats patients with congenital cardiac anomalies.


Download Here >>>

Cancer in Adolescents and Young Adults (Pediatric Oncology)

Product Details

»Book Publisher: Springer (September, 2007)
»ISBN: 3540408428
»Book author: Archie W. Bleyer, Ronald Duncan Barr

Book Description:

This is the first comprehensive book devoted exclusively to cancer in adolescents and young adults. First, an overview of cancer in this age group, specifically from age 15 to 29 inclusive, including epidemiology and the general differences in prevention, early detection, diagnosis and treatment are presented. Then, the 15 most common categories of cancers in the age group regarding their epidemiologic, risk factors/etiology, presenting symptoms and signs, diagnostic workup, treatment, survival outcomes, and adverse effects are each covered in separate chapters. The emphasis is on how the cancer in the age group differs in epidemiology, biology, clinical management and outcome from the ‘same’ cancer in younger and older patients. The individual malignancies are followed by chapters on the general psychosocial, ethical and societal aspects of managing cancer in young adult and older adolescent patients. Model programs specially designed to care for patients in the age group and surveillance of long-term adverse effects are reviewed. This book should be of interest to practitioners, researchers and students in pediatric oncology, medical oncology, radiation oncology, surgical oncology, gynaecologic oncology, oncology nursing, social work, epidemiology, public health, and health services research.


Download Here >>>

Moss and Adams’ Heart Disease in Infants, Children, and Adolescents: Including the Fetus and Young Adult

Product Details

»Book Publisher: Lippincott Williams & Wilkins (01 October, 2007)
»ISBN: 0781786843
»Book author: Hugh D Allen, David J Driscoll, Robert E Shaddy, Timothy F Feltes

Book Description:

Established since 1968 as a classic pediatric cardiology text, this two-volume work is now in its Seventh Edition. Leading international experts describe state-of-the-art diagnostic and interventional techniques for young patients with congenital and acquired heart diseases and for adult survivors of congenital heart disease. This edition’s section on pediatric cardiac intensive care has new chapters on interventricular and cardiopulmonary interactions and on the extreme premature, premature, and normal newborn. A section From the Gene to the Neonate provides in-depth coverage of genetics, fetal echocardiography, and fetal cardiology. An extensive section focuses on adult survivors of congenital heart disease. A companion Website will include the fully searchable online text.


Download Here :

Bone Densitometry in Growing Patients: Guidelines for Clinical Practice (Current Clinical Practice)

Product Details

»Book Publisher: Humana Press (2007)
»ISBN: 1588296342
»Book author: Aenor J., Ed. Sawyer

Book Description:
Bone Densitometry in Growing Patients is the first resource available for expert opinion on the use of dual energy x-ray absorptiometry (DXA) for evaluating bone density in children and adolescents. Written by internationally recognized pediatric bone researchers and clinicians, this volume is unique in its specific attention to the myriad challenges of measuring and evaluating bone density in the pediatric patient. There is sufficient technical detail presented in this volume to enable the establishment of a pediatric DXA center or the proper utilization of DXA scan information in current clinical practice.

The volume opens with a brief introduction to general concepts relating to bone health in children and an overview of all currently available densitometry techniques used in evaluating children. Subsequent chapters focus on indications for DXA studies in children and the optimal methods for acquiring, analyzing, interpreting, and reporting these scans. Current and future research applications of DXA and other modalities for studying pediatric bone health are also discussed. An extensive appendix provides useful pediatric reference data, sample forms for use in acquiring and reporting DXA data, listings of useful and relevant pediatric bone websites, and a comprehensive bibliography. This volume, which is the first pediatric DXA reference published, optimizes the accurate and responsible use of DXA in children as a tool in the clinical management of bone fragility, and thereby paves the way for the future development of appropriate intervention and treatment programs for this population.


Download Here >>>

Biomechanics

Product Details

»Book Publisher: CRC Press (25 September, 2007)
»ISBN: 0849385342
»Book author: Donald R. Peterson

Book Description:

Drawn from the third edition of the widely acclaimed The Biomedical Engineering Handbook, Biomechanics is a comprehensive presentation of the current principles and applications of biomechanics integrating both systems and subsystems models. Presenting substantial updates and revisions and a new chapter on current methods and strategies for modeling cellular mechanics, the book covers musculoskeletal mechanics including hard- and soft tissue and joint mechanics, biofluid mechanics and circulatory dynamics, the functioning of the ear, and the performance characteristics of the human body during exercise and exertion. The book includes more than 140 illustrations, 60 tables, and a variety of useful equations to assist in modeling biomechanical behaviors.


Download Here >>>

Glycovirology Protocols (Methods in Molecular Biology (Cloth))

Product Details

»Book Publisher: Humana Press (2007)
»ISBN: 1588295907
»Book author: Richard J., Ed. Sugrue
»Amazon Rating:

Book Description:

This volume reviews the increasing importance of glycosylation to the field of virology, as well as virus replication. The chapters provide an overview of glycosylation in relation to virus infection, and the generic techniques that are used to analyze and characterize glycoproteins.

Among the topics discussed in this volume are M.E. interaction between respiratory syncytial virus and glycosaminoglycans, acute respiratory syndrome coronavirus 3a protein, the C type lectins DC-SIGN and L-SIGN, N-linked glycans, and the use of two-dimensional SDS-PAGE to analyze the glycosylation heterogeneity of the respiratory syncytial virus fusion protein. Also covered in this volume are uses of monoclonal antibodies and lectins, the spike glycoprotein, secretion of respiratory syncytial vius F protein from insect cells, the expression and characterization of recombinant dengue virus E protein, and cloning, expression, and a functional analysis of patient-derived hepatitis C virus glycoproteins.

The information presented in Glycovirology Protocols will provide insight as to how the techniques of glycobiology can be applied in virology and answer most questions that are of interest to the reader.


Download Here >>>

Quantum Dots: Applications in Biology (Methods in Molecular Biology (Cloth))

Product Details
»Book Publisher: Humana Press (2007)
»ISBN: 1588295621
»Book author: Marcel P., Ed. Bruchez

Book Description:
Quantum Dots captures many diverse applications enabling utility in biological detection. Organized into five parts, the first two parts cover the use of QDs in imaging fixed and living cells (and tissues). Protocols are included for using QDs in routine (protein and structural cellular labeling), as well as enabling (single receptor trafficking, clinical pathology, correlative microscopy) applications. Part 3 shows early efforts aimed at using QDs in live animals. The final 2 parts demonstrate the versatility of QD technology in existing assay technology.

Download Here >>>

In Vitro Transcription and Translation Protocols (Methods in Molecular Biology (Cloth))

Product Details

»Book Publisher: Humana Press (2007)
»ISBN: 1588295583
»Book author: Guido, Ed. Grandi

Book Description:

A highly anticipated update of the previous edition, In Vitro Transcription and Translation Protocols, Second Edition, provides molecular biology laboratories with the most powerful techniques for exploiting in vitro transcription and translation systems.In Section One: Technologies, authors discuss the use of alternative energy systems for ATP regeneration, the efficient in vitro production of integral membrane proteins, and the high-throughput production of protein libraries using the innovative single-molecule PRC-linked in vitro expression (SIMPLEX) technology. In Section Two: Applications, authors present in vitro translation of amplified protease gene from HIV patients to select proper anti-protease drug therapy, in vitro translation of genes from human patients to diagnose biologically relevant gene mutations, use of SIMPLEX technology to select enantioselective lipases from libraries of randomly produced lipase mutants, and the in vitro transcription and translation to identify proteins in 2D-maps.


Download Here >>>

Mass Spectometry Data Analysis in Proteomics (Methods in Molecular Biology Volume 367)

Product Details
»Book Publisher: Humana Press Inc. (2007)
»ISBN: 158829563X
»Book author: Rune, Ed. Matthiesen

Book Description:
Mass Spectrometry Data Analysis in Proteomics is an in-depth guide to the theory and practice of analyzing raw mass spectrometry (MS) data in proteomics. As MS is a high throughput technique, proteomic researchers must attend carefully to the associated field of data analysis, and this volume outlines available bioinformatics programs, algorithms, and databases available for MS data analysis. General guidelines for data analysis using search engines such as Mascot, Xtandem, and VEMS are provided, with specific attention to identifying poor quality data and optimizing search parameters. Several different types of MS data are discussed, followed by a description of optimal methods for conversion of raw data into peak lists for input to search engines. Choosing the most accurate and complete databases is emphasized, and a report of available sequence databases is included. Methods for assembling expressed sequence tags (ESTs) into assembled nonredundant databases are provided, along with protocols for further processing the sequences into a format suitable for MS data. Mass Spectrometry Data Analysis in Proteomics describes publicly available applications whenever possible.

Download Here >>>

Protocols for Nucleic Acid Analysis by Nonradioactive Probes (Methods in Molecular Biology (Cloth))


Product Details
»Book Publisher: Humana Press (2007)
»ISBN: 1588294307
»Book author: Elena, Ed. Hilario

Book Description:
Protocols for Nucleic Acid Analysis by Non-radioactive Probes, Second Edition provides a firm background on the basic preparative protocols required for the analysis of nucleic acids by nonradioactive methods. Presenting the methodologies using amazing new applications, this volume offers guide chapters on nucleic acid extractions, preparation of nucleic acid blots, and labeling of nucleic acids with nonradioactive haptens. New fluorescent techniques such as Real Time PCR and microarrays are also included, allowing users to get a nonradioactive protocol implemented in the laboratory with minimum adaptation required and fastest time to results.
The protocols follow the successful Methods in Molecular Biologyâ„¢ series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.

Download Here >>>

Protein Engineering Protocols (Methods in Molecular Biology Volume 352)

Product Details
»Book Publisher: Humana Press (2007)
»ISBN: 1588290727
»Book author: Katja M., Ed. Arndt

Book Description:
Protein engineering is a fascinating mixture of molecular biology, protein structure analysis, computation, and biochemistry, with the goal of developing useful or valuable proteins. Divided into two sections, Protein Engineering Protocols reviews rational protein design strategies and directed evolutionary techniques, and their impact on protein engineering.
The first section presents design and computational strategies for protein engineering focusing on designing a protein with desired properties, including examples covering a wide range of engineering techniques, such as protein-protein interactions, DNA binding, antibody mimics, and enzymatic activity. The second section on evolutionary techniques provides step-by-step instructions on library design and statistical assessment of library quality. New methods for DNA shuffling as well as different selection strategies are also presented.
Following the successful Methods in Molecular Biologyâ„¢ series format, this volume provides a comprehensive guide to the methods used at every stage of the engineering process. By combining a thorough theoretical foundation with detailed protocols, Protein Engineering Protocols will be invaluable to all research workers in the area, from graduate students to senior investigators.

Download Here >>>

Plant Proteomics: Methods and Protocols (Methods in Molecular Biology Volume 355)

Product Details

»Book Publisher: Humana Press (2007)
»ISBN: 1588296350
»Book author: Herve, Ed. Thiellement

Book Description:
Plant Proteomics: Methods and Protocols provides up-to-date methods and protocols for plant proteomics, each written by expert researchers from leading laboratories. Experimental methodologies are explained in clear and complete detail for both the wet and dry laboratories. The methods and protocols presented in this volume will inspire the novice as well as the expert researcher to undertake new experimental endeavors in plant proteomics.

Chapters 1 and 2 describe standard protocols and chapters 3 through 10 contain optimized protocols for protein extraction of tissues such as cereal seeds, xylem, phloem sap, of woody plants, and of cellular compartments, such as chloroplasts and mitochondria. These methods rely on improvements to solubilization of proteins, which is the emphasis of Chapters 11 and 12. Chapters 13 to 23 outline methods for protein identification, including 2DLC or LC of intact proteins, mass spectrometry (MALDI-TOF and MS/MS) with proteins separated by 2D gels, blue native ID gels, and Edman sequencing. Chapters 24 to 29 focus on the rapidly expanding area of analysis of post-translational modifications and protein-protein relationships. Attention is also given to data that proteomics produces, including management of that data, and to statistical tools used for effective analysis.

Download Here >>>

Metabolomics: Methods and Protocols (Methods in Molecular Biology Volume 358)

Product Details

»Book Publisher: Humana Press (2007)
»ISBN: 1588295613
»Book author: Wolfram Weckwerth

Book Description:
Metabolomics: Methods and Protocols examines the state-of-the-art in metabolomic analysis. Leading researchers in the field present protocols for the application of complementary analytical methods, such as gas chromatography-mass spectrometry (GC-MS). Metabolomics: Methods and Protocols contains forward-looking protocols, which provide the essential groundwork for future efforts in elucidating the structure of the unknowns detected in metabolomic studies.

Part I of this volume focuses on GC-MS techniques; specifically, attention is given to metabolite profiling in blood plasma, construction and application of mass spectral and retention time index libraries, and metabolomic profiling of natural volatiles. In Part II, emphasis shifts to data integration and data mining techniques, and specific protocols discuss improving pattern recognition and biomarker selection for systems level approaches, and visualization and analysis of molecular and metabolomic data. Parts III, IV, and V examine the coupling of capillary electrophoresis and mass spectrometry, classical reversed phase liquid chromatography-mass spectrometry, and electrochemical detection of metabolites using HPLC separations coupled with coulometric electrode array detectors. In Part VI, protocols for the determination of metabolic flux rates are presented and a theoretical framework for metabolic pathway network analysis is provided. The volume concludes with an examination of cutting-edge NMR protocols.

Download Here >>>

Cardiovascular Proteomics: Methods and Protocols (Methods in Molecular Biology Volume 357)

Product Details

»Book Publisher: Humana Press (2007)
»ISBN: 1588295354
»Book author: Fernando, Ed. Vivanco

Book Description:
Cardiovascular Proteomics: Methods and Protocols presents cutting-edge protocols and strategies for proteomic evaluation of cardiovascular disease written by pioneering researchers in the field. Topics explored in this comprehensive volume include obtaining specific heart proteins, cutting-edge techniques for identifying risk biomarkers of atherome plaque rupture, analyzing the secretome of explanted endarterectomies cultured in vitro, and phage display techniques for deciphering the molecular diversity of blood vessels. Detailed protocols for the isolation of short- and long-term culture of the adult mouse cardiac myocytes are also included.

Numerous advanced proteomic techniques are addressed, including protein separation by two-dimensional electrophoresis and two-dimensional difference gel electrophoresis, liquid chromatography coupled to mass spectrometry, and the SELDI-TOF approach to searching for biomarkers of stroke in human serum or of hypertension in the serum of animal models. Proteomic strategies and protocols for studying the proteome of endothelial, arterial smooth muscle cells, foam cells, and circulating blood monocytes constitute a major element of this text. Cutting-edge techniques for the analysis of subproteomes from isolation to final characterization and the characterization of posttranslational modifications are also addressed. This useful snapshot of current proteomic techniques is a single source for protocols for the identification and validation of novel biomarkers and targets in cardiovascular diseases.

Download Here >>>

Product Details

»Book Publisher: Humana Press (2007)
»ISBN: 1588298906
»Book author: Mouldy, Ed. Sioud

Book Description:
Target Discovery and Validation Reviews and Protocols, Volumes 1 and 2 review the most progressive and current methods for drug target discovery and validation. These volumes explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for cancers and autoimmune disorders.

Volume 1 focuses on novel and innovative techniques, and presents the most up-to-date protocols available for maximizing the likelihood of achieving target-selective inhibition in vivo while minimizing side effects. The profound impact of genomics, proteomics and bioinformatics on target discovery is explored, and specific attention is given to the role of transgenic and knockout animals in functional genomics and target validation. Cancer researchers will find tremendous value in the molecular classification of breast cancers and the review of protocols for tumor antigens and cancer vaccines. The methods and protocols collected here, all reviewed by leading scientists and clinicians, present the practical details necessary for translating the enormous discovery potential of the genome into real therapeutic products.

Volume 2 collects all the practical details required for efficient translation of discovered targets into real pharmaceutical drugs. Specific targets in cancers and autoimmunity are described and the potential of using siRNAs, antisense oligonucleotides and RNA aptamers in patients is reviewed. This volume explores the tremendous impact of the application of genotyping and gene expression profiling on the future of healthcare, and presents cutting-edge protocols to aid in bringing agents against specific targets closer to application in the clinic.

Collectively, these volumes provide a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical application. For researchers, an understanding of available methods aids in the creation of innovative experiments in the laboratory, and the successful translation of target discovery to real therapeutics.

Download Here >>>